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KMID : 1145120210190010139
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Asian Journal of Beauty and Cosmetology
2021 Volume.19 No. 1 p.139 ~ p.146
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Effect of Run Ze Tonic in Mice with Kidney-Yin Deficiency
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Liu Shuo
Ma Si-yao
Zhu Wen-yi
Liang Jia
Meng Hong
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Abstract
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Purpose : To observe the effects of Run Ze Tonic on thyroid hormone, adrenal function, sex hormones and cyclic nucleotide of mice with kidney-yin deficiency.
Methods : ICR mice were randomly grouped into normal control group, model group, Run Ze Tonic high dose group, the middle dose group and low dose group, male and female in half. The kidney-yin deficiency mice models were established by intragastric administration of levothyroxine sodium before intragastric administration of corresponding drugs once a day for 10 consecutive days. One day after the last administration, the effects were observed by measuring weight. And tetraiodothyronine (T4), triiodothyronine (T3), thyrotropin (TSH), corticotropin releasing hormone (CRH), adrenocorticotropic hormone (ACTH), corticosterone (CORT), testosterone (T), estradiol (E2), cyclic adenosine monophosphate (cAMP), cyclic guanosine monophosphate (cGMP) were tested by ELISA method.
Results : Compared with the model group, the body weight, TSH level increased significantly (p<0.01, p<0.05), and T3, T4, ACTH level decreased significantly in high dose group (p<0.01, p<0.05). The E2 level in female decreased significantly in high dose group (p<0.01), the same as the ratio of E2/T (p<0.01). The T level in male increased significantly in high dose group (p<0.01), the same as the ratio of E2/T (p<0.01). And cAMP level decreased in the high dose group(p<0.05).
Conclusion : Run Ze Tonic may play the role of nourishing yin and strengthening kidney by adjusting hormone level disorder, adrenal cortex function and balancing energy metabolism in endocrine system.
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KEYWORD
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Run Ze Tonic, Kidney-yin deficiency, Adrenal function, Sex hormone, Cyclic nucleotide
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